Non cholinergic toxicity of Sarin.

Sarin attacks occurred both in Matsumoto and in Tokyo in 1994-1995; more than 15 people died because of such attacks. The acute toxic effect of Sarin nerve gas (organophosphorus: OP) produces miotic pupils as well as reduced cholinesterase (ChE) activities, which are nicotinic and muscarinic signs. A cholinergic sign may not be the sole mechanism of OP toxicity. Suzuki et al (1) described the following findings which are worthy of discussion: hypokalemia, depression of triglyceride, hypocapnea, change in electrolytes, etc.